Outputs
Scientific Outputs
Publications
Wahis J., Akkaya, C., Kirunda, A.M., Mak, A., Zeise, K., Verhaert, J., Gasparyan, H., Hovhannisyan, S., Holt M.G. The astrocyte α1A-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex. Glia, 1–19 (2024)
Hendrix, E., Vande Vyver, M., Holt, M., Smolders, I. Regulatory T cells as a possible new target in epilepsy? Epilepsia 00:1–11 (2024)
Bielefeld, P., Martirosyan, A. , Martín-Suárez, S., Apresyan, A., Meerhoff, G. F., Pestana, F., Poovathingal, S., Reijner, N., Koning, W., Clement, R. A., Van der Veen, I. Toledo, E. M., Polzer, O., Durá, I., Hovhannisyan, S., Nilges, B. S., Bogdoll, A., Kashikar, N. D., Lucassen, P. J., Belgard, T. G., Encinas, J. M., Holt, M. G. & Fitzsimons, C. P. Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nat Commun 15, 5222 (2024).
Martirosyan, A., Ansari, R., Pestana, F. et al. Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution. Mol Neurodegeneration 19, 7 (2024).
Pereira, M. J., Ayana, R., Holt, M. G. & Arckens, L. Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease. Frontiers in Cell and Developmental Biology 11, (2023).
Lemaitre, P. et al. Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain. EMBO Molecular Medicine 15, e16805 (2023).
Viana, J. F. et al. Astrocyte structural heterogeneity in the mouse hippocampus. Glia 71, 1667–1682 (2023).
Holt, M. G. Astrocyte heterogeneity and interactions with local neural circuits. Essays in Biochemistry 67, 93–106 (2023).
Edwards-Faret, G. et al. A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions. Neuroscience 508, 40–51 (2023).
Shah, D., Gsell, W., Wahis, J., Lucktt, E.S., Jamouelle, T., Vermaercke, B., Preman, P., Moechars, D., Hendrickx, V., Jaspers, T., Craessaerts, K., Horré, K., Wolfs, L., Fiers, M., Holt, M.G., Thal, D.R., Callaerts-Vegh, Z., D’Hooge, R., Vandenberghe, R., Himmelreich, U., Bonin, V., De Strooper, B. Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease. Cell Rep. 40(8):111280 (2022).
Frontzek, K. et al. A conformational switch controlling the toxicity of the prion protein. Nat Struct Mol Biol 29, 831–840 (2022).
Yshii, L. et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol 23, 878–891 (2022).
Featured in:
- Conversations with Immunologists podcast
- BrainPost
- News and Views (restricted access)
- Nature Research Briefing (restricted access)
- The Times UK
- VRT Flanders
- ABC Spain
More press releases on this paper:
Abdelfattah, A. et al. Neurophotonic tools for microscopic measurements and manipulation: status report. NPh 9, 013001 (2022).
Marino, M. & Holt, M. G. AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System. Frontiers in Neurology 13, (2022).
Shinmyo, Y. et al. Localized astrogenesis regulates gyrification of the cerebral cortex. Sci. Adv. 8, eabi5209 (2022).
Participation in Conferences
10-12.07.2024 | Sissa (International School for Advanced Studies) | Trieste, Italy
Talk: “Astrocytes: Central players in differential synaptogenesis.”
Matthew Holt (ERA Chair Holder)
09.05.2024 | IJUP 2024, 17th edition | University of Porto, Portugal
Poster: “Validation of a genetic system to unravel the astrocyte secretome using proximity biotinylation”
Luísa Florido (M.Sc. student)
03.05.2024 | V Symposium of Biochemistry | University of Minho, Braga, Portugal
Talk: “Exploring Astrocytic Heterogeneity: Implications in Brain Function”
Rafaela Seixas (Ph.D. student)
22.04.2024 | Invited Talk | University of Padova, Italy
Talk: “AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer’s disease model”
Matthew Holt
05.04.2024 | VIII Portuguese Glia Meeting | ICVS, Braga Portugal
Poster: “Targeting the Inhibitory Tripartite Synapse in the Context of Autism Spectrum Disorder: Astrocytes in the Spotlight”
Domenico Natale (external Ph.D. student)
18-22.03.2024 | Gordon Research Conference: Antibody Biology and Engineering | Italy
Talk: “Bypassing the Blood Brain Barrier: Exploiting CNS Penetrant AAV Vectors for Localised Biologics Production and Activity”
Matthew Holt
26.02.2024 | Invited Talk | Institut du Cerveau et de la Moelle épinière (ICM), France
Talk: “Astrocytes: central players in differential synaptogenesis“
Matthew Holt
09.02.2024 | 54th Meeting of the Portuguese Society of Pharmacology | Nova Medical School, Lisbon, Portugal
Talk: “DBH inhibitor Nepicastat may be a potential prophylactic approach for post-traumatic stress disorder”
Rafaela Seixas (Ph.D. student)
18-20.09.2023 | 3rd Single-Domain Antibodies Symposium | Paris, France
Talk: “AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer’s disease model”
Matthew Holt
5-6/08/2023 | International Society for Neurochemistry Satellite Meeting | Braga, Portugal
Talk: “Astrocyte heterogeneity and interactions with local circuits”
Matthew Holt
08-11/06/2023 | 16th European Meeting on Glial Cells in Health and Disease. | Berlin, Germany
Poster: “Structural analysis of astrocytes in different experimental conditions.” — Barsanti, S. et al
Poster: “Astrocyte structural heterogeneity in the mouse hippocampus.” — Machado, J.L. et al
Poster: “The astrocyte a1A-adrenoreceptor is an essential component of the neuromodulatory system in mouse visual cortex.” — Wahis, J. et al
03-05.05.2023 | FENS Satellite Symposium | Algarve, Portugal
Talk: “New tools to study the brain in health and disease“
Matthew Holt
11.01.2023 | Astrocytes and APOE mini-symposium | KU Leuven, Belgium
Poster: “The emerging concept of astrocyte heterogeneity: Consequences for CNS function”
Matthew Holt
18.10.2022 | VI Portuguese Glia Meeting | i3S, Porto, Portugal
Keynote Talk: “Molecular Heterogeneity of Astrocytes: Potential Implications for Development and Function”
Matthew Holt
Poster: “Morphological Analysis of Astrocytes in Different Preparations”
Poster: “Unravelling cell type specific response to PD at single cell resolution”
Poster: “Targeting the Inhibitory Tripartite Synapse in the Context of Autism Spectrum Disorder: Astrocytes in the Spotlight”
Poster: “Decoding the Mechanisms of Neuronal Wiring: a Lesson from Down Syndrome”
Poster: “Star Power – Elucidating the Mechanisms by Which Astrocytes Promote Adult Brain Plasticity”
31.07.2022 | Alzheimer’s Association International Conference (AAIC) | San Diego, USA
Talk: “AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer’s disease model”
Matthew Holt
20.07.2022 | Invited Talk | Institute of Molecular Medicine (IMM), Lisbon, Portugal
Talk: “Astrocytes: Master regulators of inhibition and plasticity?”
Matthew Holt
09-13.07.2022 | FENS Forum 2022 International Neuroscience Conference | Paris, France
Poster: “Morphological Analysis of Astrocytes in Different Preparations”
Poster: “Astrocyte Structural Heterogeneity in the Mouse Hippocampus”
Talk: “The emerging concept of astrocyte heterogeneity: consequences for CNS function.”
Matthew Holt
07.07.2022 | FENS Forum | DFG-organised Satellite symposium on astrocytes | Paris, France
Talk: “Astrocytes: Master regulators of inhibition and plasticity?”
Matthew Holt
17.06.2022 | Dutch Neuroscience Meeting | Tiel, The Netherlands
Chair / Session organizer: “Spatial Transcriptomics: mapping gene expression and cell populations in the brain”
Matthew Holt
6-9.06.2022 | Advances in Genome Biology and Technology | Florida, USA
Poster: “Mapping transcriptome heterogeneity in the CNS with single cell resolution using highly multiplexed spatial transcriptomics”
Matthew Holt
24.05.2022 | Science Europe Workshop on Widening Participation and Spreading | Online
Talk: “Experiences of an ERANET Chair”
Matthew Holt
09.05.2022 | Belgian Neuroscience Society Meeting | Brussels, Belgium
Talk: “Astrocytes: Master regulators of inhibition and plasticity?”
Matthew Holt
22.09.2022 | i3S Group Leaders’ Seminar Series | i3S, Porto, Portugal
Seminar: “Astrocytes: Master regulators of inhibition and plasticity”
Matthew Holt
Organization / co-organization of events
International Astrocyte Summer School | Bertinoro, Italy
Matthew Holt (ERA Chair Holder)
i3S Neuro Day: Meeting of i3S Program of Neurobiology and Neurologic Diseases (PNND) | Biblioteca Almeida Garret, Porto, Portugal
Sponsored the participation of Prof. Dr. Pierre Vanderhaegen
04.11.2022 | i3S Neuro Day: Meeting of i3S Program of Neurobiology and Neurologic Diseases (PNND) | Fundação Dr. António Cupertino De Miranda | Porto
Members of Organizing Committee: Matthew Holt, Olga Sin
18.10.2022 | VI Portuguese Glia Meeting | i3S, Porto
Chairs: Matthew Holt and João Relvas
Members of Organizing Committee: Olga Sin, Matthew Holt, João Relvas and Teresa Summavielle
Seminars organization
05.12.2023 | Satellite Seminar
Vanessa Coelho Santos, VCoelho-Santos Lab, Coimbra, Portugal